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Aptamer-based biosensors and application in tumor theranostics.

National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, China. Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering and Biomedical Engineering, Faculty of Engineering, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Yong Loo Lin School of Medicine, Clinical Imaging Research Centre, Centre for Translational Medicine, National University of Singapore, Singapore, Singapore. Yong Loo Lin School of Medicine, Nanomedicine Translational Research Program, NUS Center for Nanomedicine, National University of Singapore, Singapore, Singapore.

Cancer science. 2022;(1):7-16
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Abstract

An aptamer is a short oligonucleotide chain that can specifically recognize targeting analytes. Due to its high specificity, low cost, and good biocompatibility, aptamers as the targeting elements of biosensors have been applied widely in non-invasive tumor imaging and treatment in situ to replace traditional methods. In this review, we will summarize recent advances in using aptamer-based biosensors in tumor diagnosis. After a brief introduction of the advantage of aptamers compared with enzyme sensors and immune sensors, the different sensing designs and mechanisms based on 3 signal transduction modes will be reviewed to cover different kinds of analytical methods, including: electrochemistry analysis, colorimetry analysis, and fluorescence analysis. Finally, the prospective advantages of aptamer-based biosensors in tumor theranostics and post-treatment monitoring are also evaluated in this review.

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Publication Type : Review

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